Wang C, Schmid CH, Fielding RA, et al. Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial. BMJ. 2018 Mar 21;360:k851.
Discipline Area Score
Physician 5 / 7

OBJECTIVES: To determine the effectiveness of tai chi interventions compared with aerobic exercise, a current core standard treatment in patients with fibromyalgia, and to test whether the effectiveness of tai chi depends on its dosage or duration.

DESIGN: Prospective, randomized, 52 week, single blind comparative effectiveness trial.

SETTING: Urban tertiary care academic hospital in the United States between March 2012 and September 2016.

PARTICIPANTS: 226 adults with fibromyalgia (as defined by the American College of Rheumatology 1990 and 2010 criteria) were included in the intention to treat analyses: 151 were assigned to one of four tai chi groups and 75 to an aerobic exercise group.

INTERVENTIONS: Participants were randomly assigned to either supervised aerobic exercise (24 weeks, twice weekly) or one of four classic Yang style supervised tai chi interventions (12 or 24 weeks, once or twice weekly). Participants were followed for 52 weeks. Adherence was rigorously encouraged in person and by telephone.

MAIN OUTCOME MEASURES: The primary outcome was change in the revised fibromyalgia impact questionnaire (FIQR) scores at 24 weeks compared with baseline. Secondary outcomes included changes of scores in patient's global assessment, anxiety, depression, self efficacy, coping strategies, physical functional performance, functional limitation, sleep, and health related quality of life.

RESULTS: FIQR scores improved in all five treatment groups, but the combined tai chi groups improved statistically significantly more than the aerobic exercise group in FIQR scores at 24 weeks (difference between groups=5.5 points, 95% confidence interval 0.6 to 10.4, P=0.03) and several secondary outcomes (patient's global assessment=0.9 points, 0.3 to 1.4, P=0.005; anxiety=1.2 points, 0.3 to 2.1, P=0.006; self efficacy=1.0 points, 0.5 to 1.6, P=0.0004; and coping strategies, 2.6 points, 0.8 to 4.3, P=0.005). Tai chi treatment compared with aerobic exercise administered with the same intensity and duration (24 weeks, twice weekly) had greater benefit (between group difference in FIQR scores=16.2 points, 8.7 to 23.6, P<0.001). The groups who received tai chi for 24 weeks showed greater improvements than those who received it for 12 weeks (difference in FIQR scores=9.6 points, 2.6 to 16.6, P=0.007). There was no significant increase in benefit for groups who received tai chi twice weekly compared with once weekly. Participants attended the tai chi training sessions more often than participants attended aerobic exercise. The effects of tai chi were consistent across all instructors. No serious adverse events related to the interventions were reported.

CONCLUSION: Tai chi mind-body treatment results in similar or greater improvement in symptoms than aerobic exercise, the current most commonly prescribed non-drug treatment, for a variety of outcomes for patients with fibromyalgia. Longer duration of tai chi showed greater improvement. This mind-body approach may be considered a therapeutic option in the multidisciplinary management of fibromyalgia.


Comments from MORE raters

Physician rater

This study provides helpful evidence supporting the use of Tai Chi as an alternative to aerobic exercise for help in fibromyalgia. One concern is that the criteria for fibromyalgia in the study used older criteria, the presence of trigger points. Another concern I have is the clinical significance of the results, regardless of the importance of the patient survey score changes; however, outcomes were similar for both exercise groups. I did study Tai Chi for a year in Boston - the site of the training in this study. I believe Tai Chi is very appealing for many people. For home practice, you don't need to go out into bad weather, you just need a large uncluttered space. It can be restful and meditative. It is wonderful to be able to offer this alternative to patients with fibromyalgia.

Physician rater

I am a bit worried about the validity of this RCT: 1) big attrition (~27%); 2) we know that patients with fibromyalgia are resistant to exercise as a treatment modality (they think they should be rested), and, with an open trial, they might have a strong prior belief that an alternative treatment is going to be better.

Physician rater

This helps to clarify some things. A longer Tai Chi program is better. There was no difference in the results between the instructors recruited.

Physician rater

Tai chi appears to be a reasonable non-drug option for treatment of fibromyalgia. However, patients were recruited from a tertiary care center and adherence to the treatment program was strongly encouraged by phone and during follow-up visits. Alas, for reasons of adherence, cost, and the messiness of life, likely the benefit would be less impressive when applied in community settings.

Physician rater

It makes sense to me that gently guided exercise helps folks with fibromyalgia syndrome. I will encourage my patients to exercise with this new bit of data.
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