Kroenke K, Baye F, Lourens SG, et al. Automated Self-management (ASM) vs. ASM-Enhanced Collaborative Care for Chronic Pain and Mood Symptoms: the CAMMPS Randomized Clinical Trial. J Gen Intern Med. 2019 Jun 21. pii: 10.1007/s11606-019-05121-4. doi: 10.1007/s11606-019-05121-4. (Original study)

BACKGROUND: Chronic musculoskeletal pain is often accompanied by depression or anxiety wherein co-occurring pain and mood symptoms can be more difficult to treat than either alone. However, few clinical trials have examined interventions that simultaneously target both pain and mood conditions.

OBJECTIVE: To determine the comparative effectiveness of automated self-management (ASM) vs. ASM-enhanced collaborative care.

DESIGN: Randomized clinical trial conducted in six primary care clinics in a VA medical center.

PARTICIPANTS: Two hundred ninety-four patients with chronic musculoskeletal pain of at least moderate intensity and clinically significant depressive and/or anxiety symptoms.

INTERVENTION: ASM consisted of automated monitoring and 9 web-based self-management modules. Comprehensive symptom management (CSM) combined ASM with collaborative care management by a nurse-physician team. Both interventions were delivered for 12 months.

MAIN MEASURES: Primary outcome was a composite pain-anxiety-depression (PAD) z-score consisting of the mean of the BPI, PHQ-9, and GAD-7 z-scores: 0.2, 0.5, and 0.8 represent potentially small, moderate, and large clinical differences. Secondary outcomes included global improvement, health-related quality of life, treatment satisfaction, and health services use.

KEY RESULTS: Both CSM and ASM groups had moderate PAD score improvement at 12 months (z = - 0.65 and - 0.52, respectively). Compared to the ASM group, the CSM group had a - 0.23 (95% CI, - 0.38 to - 0.08; overall P = .003) greater decline in composite PAD z-score over 12 months. CSM patients were also more likely to report global improvement and less likely to report worsening at 6 (P = .004) and 12 months (P = .013).

CONCLUSIONS: Two intervention models relying heavily on telecare delivery but differing in resource intensity both produced moderate improvements in pain and mood symptoms. However, the model combining collaborative care led by a nurse-physician team with web-based self-management was superior to self-management alone.


Discipline Area Score
Physician 5 / 7
Psychologist 5 / 7
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Comments from MORE raters

Physician rater

This trial does not convince me about the clinically usefullness of the CSM over the ASM. The key fact is the estimated effect size of 0.35 made by the authors as a matter for comparisons. It is not a real data but a data compound between small and moderate effect size shown in previous studies.

Physician rater

As telemedicine and collaborative care models of treatment become more common, studies such as this one have increasing relevance.

Psychologist rater

This interesting study indicates that clinical contact improved outcomes to a degree. The homogeneous subject sample was a limitation.
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